A Big Picture Look at Cushings Disease and Diabetes

By |2016-12-29T16:26:25-05:00Updated: June 9th, 2016|Pet Care, Pet Newsletter|16 Comments

There are some diseases I just despise. It’s not that I like any disease, but some just make me want to crawl in a hole. Cushings disease is one of them. Cushings is short for hyperadrenocortisism, a state where the body makes too much steroid, either from a pituitary tumor or from an adrenal tumor. The tumor can be benign or malignant, but regardless the excess steroid can wreak havoc on the pet. It’s usually a forever treatment for the life of the pet (except for the less common adrenal mass that sometimes can be surgically removed), and it’s very expensive to treat. If you think treating diabetes is expensive, you should see the bills that pile up with Cushings disease! The initial and ongoing blood tests are expensive. The medication is expensive. And the vast majority of pets affected will be a ‘Cushingoid’ for life, requiring the medication for life. You see why I despise this disease!

Why am I going on about one of my least favorite diseases? Because there is a link between Cushings disease and diabetes. Cushings patients produce too much steroid. Steroids cause insulin resistance. Some diabetic pets actually became diabetic secondary to having Cushings disease from the insulin resistance caused by steroids. It is difficult to regulate a diabetic pet that is also Cushingoid. There are a few things you should know about this disease if your pet is diabetic.

Cushings can affect both dogs and cats, but it is better understood and much more common in our canine friends than our feline friends. Personally, I think it is often more affordable for families to go straight to an internist rather than have their regular veterinarian diagnose and treat this disease. Additionally, treatment of this Cushingoid state can result in a crisis situation and requires very close monitoring, ideally by someone well-versed in the disease. A general practitioner like me might come across one or 2 Cushingoid dogs per year, but internists manage many Cushingoid pets all the time. When dealing with diagnostic and ongoing monitoring tests that are as costly as with this disease, you want a specialist (or at least a GP who sees a lot of them) to manage your pet. Medicine is getting so specialized that as my neighbor once put it, “If you have one doctor to treat your right foot you need a second doctor to treat your left foot”.

Personally, when I suspect Cushings disease I send the pet to my local internist. I’m very lucky that I have an amazing veterinary internist just a couple miles from my general practice, and his practice is open 24/7. With that being said you will understand that I am not a pro at this disease. Nonetheless, I can point out important points I think a layperson with a diabetic pet should know.

How do we treat Cushings disease? For years vets used a drug called Mitotane which selectively destroyed part of the adrenal gland. It required daily vet contact at initiation of treatment as Mitotane could cause adrenal necrosis and a pet could go into a medical crisis and die if left untreated. Yikes! A new medication called Trilostane is now available to treat Cushings. Trilostane came out about 8 years ago and is less likely to cause adrenal necrosis, although it is still feasible. Trilostane reversibly inhibits the production of cortisol in the body. I don’t feel quite so strongly about referral to an internist these days as I used to back when all vets had in our tool kit was Mitotane. Most vets use Trilostane now.

So here goes with the nitty gritty bullet points on Trilostane!

  • Give Trilostane with food. It is absorbed 3 times better with food than on an empty stomach. For a diabetic pet this means at mealtime the pet should get the Trilostane and insulin at the same time, when Fluffy is eating.
  • When your vet does the monitoring blood work (chemistry, electrolytes and a test called an ACTH stim), give the Trilostane in the morning. The ACTH stim should be done 4 to 6 hours after the Trilostane is given. If you give Trilostane at the evening meal that means you’d need to do the ACTH stim test at midnight for an accurate result. That would make your vet grouchy!
  • Don’t break apart the capsules. You are treating Fluffy, not yourself. You don’t want to affect your own hormones!
  • Some vets get Trilostane compounded to save their clients money. It’s important that they check with the compounding pharmacy to verify they are using medical grade Trilostane rather than chemical grade. Unfortunately, a good chunk of the expense of treating these patients is the re-check lab work (up to every 3 months for the life of the pet). Compounding probably isn’t worth the minor savings. I’d stick with the brand name stuff with this disease. The one brand available in the USA is called Vetoryl.
  • Sometimes pets feel puny at the start of treatment. This may simply be from steroid withdrawal. Be prepared for this and know it will get better. On the other hand, the diabetes will be easier to control and the pet may feel better without overt steroid withdrawal signs. Anticipate lowering the insulin dosage as the steroid production comes down to normal! Keep a very close watch on the blood glucose and adjust the insulin accordingly to avoid hypoglycemia.
  • According to Dechra, the manufacturer of Vetoryl, 4 of 5 pets do well getting Trilostane once a day. That leaves 1 of 5 needing it twice daily. Diabetic pets should get it twice daily. Why? It’s about the duration of a dose. The dose is quickly absorbed orally and is out of the body in 10 to 18 hours. Nondiabetic pets might be okay with a little excess steroid for the last part of a 24 hour period. Diabetics don’t do well with any excess steroid!
  • If your pet is diabetic AND Cushingoid, the total daily dose should be split in 2 and given 12 hours apart.
  • Can we use Trilostane in cats? Some vets have used Trilostane on cats, but it is extralabel use for felines. Cushings disease is a known disease in cats but is much less common than in dogs. If your diabetic cat is difficult to regulate despite your best efforts, your vet may contemplate the possibility of concurrent Cushings disease.

As always, I enjoy getting emails from readers. Feel free to email me at joi.suttondvm@adwdiabetes.com


NOTE: Consult your veterinarian first to make sure my recommendations fit your pets special health needs.

About the Author:

Dr. Joi Sutton is a 1993 graduate from Oregon State University. She has practiced both in emergency medicine and general practice. Dr. Sutton has done extensive international volunteer work though Veterinary Ventures, a nonprofit organization that takes teams of veterinarians to undeveloped countries for humane medical care. She also runs a small animal practice in South Florida.

16 Comments

  1. ilona January 23, 2018 at 3:29 am - Reply

    my dog was diagnosed with cushing 4 years ago, for threes years she been treated with vetoryl but last winter she was hospitalized with stomach ulcers that gave her bad animia so together with doctor we decided to keep her on homeopathic products. She did good for a year but now she hospitalized again because her little mamory gland tumar turn bad over a night and today i also learned that she is a diabetic;((…. i dont know what to do…. if she will get better can i just treat her with diabetes insulin shots? without treating cushing

    • Dr . Joi Sutton January 24, 2018 at 6:04 am - Reply

      Oh my, she has a lot going on. Unfortunately, it is extremely difficult to regulate diabetes without also treating the underlying cushings disease.

    • Lauree February 10, 2018 at 8:29 pm - Reply

      I have a 5 year old doberman with Diabetes and newly diagnosed Cushings. You absolutely must have the cushings in check to regulate the diabetes. There are 2 awesome Facebook groups for both diseases. One is called Diabetic Dog owners and the other is Cushings disease awareness for dog parents. Both groups are packed with information in their files and most of your questions can be answered there. Good luck to you and your pup.

  2. aMANDA March 15, 2018 at 9:16 am - Reply

    My dog was diagnosed with diabetes a month ago. After a week of increase the insulin, it was confirmed he had Cushings also. He is on 30 mg twice a day of Trilaostane and 19 units of Novolin twice a day and still his glucose is in the 300-400 range. I need any suggestions in helping to get his glucose to normal levels.

    • Dr . Joi Sutton March 18, 2018 at 10:15 pm - Reply

      It can be quite difficult regulating the diabetes until the Cushings disease in under control. You are likely due for an acth stim test to evaluate the trilostane dosage.
      As a side note, levemir lasts longer than NPH in diabetic dogs and you might have more success with it than NPH. Levemir is quite potent in dogs.
      Chat with your vet and have your vet do the follow up acth stim test.
      Good luck! Joi

  3. John Lisofsky October 11, 2018 at 10:48 pm - Reply

    My dog a 9 yr old Border Collie was diagnosed with diabetes back in July and we tried to regulate it with food, but no luck. She has now been on insulin for a month and her blood sugars levels are coming down. Tested her today and they are at 360 from 491. But she is panting excessively and seems very uncomfortable. And lost a lot of weight (she is starting to put some back on). I was wondering if I should suggest to my vet about the possibility of Cushing’s? He thought the panting might be cause she had some pain in her back, which she might and gave us antiinflammatories. But I am not convinced the excessive panting is from that. Thanks

    • Dr . Joi Sutton October 17, 2018 at 8:54 pm - Reply

      Panting can be from numerous causes from cushings to discomfort to feeling hot or anxious. There are often clues in the chemistry profile that might cause your vet to suspect cushings disease. Good idea chatting with your vet. 🙂

  4. Cindy July 22, 2019 at 4:16 pm - Reply

    Our long haired dachshund, Max, was diagnosed with Cushings October 2018. Deveopled diabetes February 2019. He is now taking 15 mg Vetoryl every 12 hours and his Cushings is under control. However, he is insulin resistant. He is taking Vetsulin. Glucose curve on 7/7/19 using iPet Pro Glucometer was 5:30 a.m. HI/over 600, 7:30a.m. 540, 9:30 a.m. 315, 11:30 a.m. 393, 1:30 p.m. 491, 3:30 p.m. 420, 5:30 p.m. 376. This is a typical day for us. Max has not been regulated at all since diagnosed.

    • Dr . Joi Sutton July 28, 2019 at 1:08 pm - Reply

      It is typically quite difficult to regulate a diabetic that is also cushingoid. I’m glad to hear that your vet is splitting the vetoryl to twice daily—that’s quite important to diabetic cushingoid dogs. Be sure that you are addressing other causes of insulin resistance such as obesity, dental disease and occult urinary tract infection (rampant in uncontrolled diabetic pets). If you still can’t reach decent regulation consider asking your vet for a referral to a vet internist.
      Best, Dr Joi

  5. Maggie August 17, 2019 at 2:17 pm - Reply

    My dog has been a well regulated diabetic for 2 years this summer. She has recently started panting a lot at night. Any chance she could have developed Cushings this far in?

    • Dr . Joi Sutton August 21, 2019 at 10:50 pm - Reply

      Yes, it is possible that your pet could have cushings, but there are other potential causes of panting. Pain, respiratory disease, or even just trying to cool off from the summer heat are other potential causes of panting. Do take your pet to your veterinarian for a check up!

  6. Barbara March 2, 2020 at 4:14 pm - Reply

    Hi, i adopted a pup 2 years ago and then found out she was diabetic. We struggled for 2 years and have been unable to get her regulated. All along I wondered if she was still producing some insulin because she drops really fast after dosing and then her levels go back up. I took her to Oregon State Vet College and they found a mass on one of her adrenals. At first they recommended surgery but then did Dex test and wanted to start Trilostane instead. We’ve been on for about a week and she is still drinking & urinating a lot and just as hungry as ever all the time. How do we know the Trilostane is helping? When should we see some results? Why aren’t they treating the adrenal mass?

    • Dr . Joi Sutton March 6, 2020 at 8:45 pm - Reply

      These are all good questions and should be asked of the veterinarians at the college. You are in good hands at a teaching university.
      It can take a bit of time to see improvement on trilostane. Follow up lab or is needed to adjust the dose of trilostane.
      Most cushingoid dogs do better on twice daily trilostane, but all diabetic dogs should be on twice daily trilostane as trilostane doesn’t last a full 24 hours.
      You’d need to ask your veterinarians at the vet school why they chose not to remove the mass.
      Best,
      Joi

  7. Laurie March 17, 2020 at 1:18 pm - Reply

    My 7 1/2 year old Siberian Husky has had Cushings for about 2 years. We had it under control by August 2019. Then In Sept. 2019 he tore his ACL and had surgery in Sept. 2019. He had complications with it not healing and bleeding. The surgeon said once it heals he could go in and take the plate out which our dog was rejecting. In Jan. 2020 the surgeon did another exam and said it was not healing and most likely they would not be able to take the plate out. He had also done blood work and we found out he now has diabetes. His levels were 600 and the vet suggested we should put him down. The vet said it is hard t o control both diseases. I said I want to try so I did but that week our dog thew up a lot, wasn’t really eating or taking his meds. He then was up all night outside trying to go to the bathroom. When he would come in for a few minutes he would cry. We took him to the vets in the morning and they gave him some more meds. By the afternoon his stools had blood in them. We made the hardest decision to put him down. Now we have such guilt thinking we should have taken him to the hospital and maybe we could have gotten everything under control. So when do you put a dog dog with these diseases?

  8. Sheri Greenstein July 9, 2020 at 1:33 pm - Reply

    My dog has a very complicated situation, the details of which I won’t bore you. Been treated diabetic for 3 years and was simultaneously on Leflunemide for pemphigus. She was going great nil issues. About 8 weeks ago the vet (dermatology specialist) recommending ceasing the leflunemide as her white cells were low. Ever since things have gone a bit crazy. Her diabetes specialist was always suspicious of cushings but with insulin and leflunemide she was absolutely fine but now since ceasing the leflunemide she is panting like crazy and I increased her insulin to see if maybe it was just the diabetes (leflunemide lowers blood glucose) but her glucose is normal and her symptoms of cushings persist. My question is could the leflunemide have been suppressing the cushings?

    • Dr . Joi Sutton July 12, 2020 at 10:16 pm - Reply

      Good question. I’ve not used leflunemide personally, so I can’t answer. This is a question for your dermatologist and internist who have used this medication. It sound so like the timing coincides with the of the withdrawal of the drug, but it could also be a progression of the Cushings disease.

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